For the game against City, Brighton will be without Beram Kayal and Sam Baldock, who are both injured; Glenn Murray, Anthony Knockaert and Solly March all face late fitness tests.
In spite of City's lavish summer spending, which has seen the club surpass the £220m barrier, Guardiola anticipates a tough start for the new season.
"We know from working in preseason on the training pitch what our game plan is going to be in most games". "But we've got quality in the team and eventually it made the difference".
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City have had a good warm-up going into the start of the campaign despite a 2-0 defeat to Manchester United in their opening clash of their pre-season tour of America.
"Six players were out of contract and in the last six or seven years, we didn't buy full-backs".
In the International Cup of Champions, Guardiola's team defeated Tottenham 3-0 and Real Madrid 4: 1, but lost to Manchester United 0: 2.
"We spoke about that", Guardiola said after Saturday's last game, "what happened with Liverpool and what happened at Chelsea".
Brighton boss Chris Hughton: "For 70 minutes I thought we were good, there's only one way we can play against a team like City. With the results this weekend, I'm happy to win away".
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Brighton's Dale Stephens headed onto his own post 24 minutes in, before Gabriel Jesus had a goal chalked off for handball.
"The first game especially with the newly promoted, when they have the fans, no pressure is always hard". We were stable but we have to try to improve.
It didn't really begin at all for City and Guardiola last season, which is why the pressure has increased ahead of 2017-18; a second successive season without a trophy would be unthinkable, not only for City's hugely ambitious owners, but also for the club's manager, who boasts a CV that is all about winning.
"There's only one way a team like ourselves can play against them, and that's to keep it tight and frustrate them". We will get the answer only in time.
"From my experience, the first game especially with a new promoted club is always hard, when you have the passion, the fans and no pressure at all but we did it".
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