April 21, 2018

Bharat Biotech's typhoid vaccine gets World Health Organization nod

12 January 2018, 08:59 | Silvia Roy

Bharat Biotech's typhoid vaccine gets World Health Organization nod

Bharat Biotech's typhoid vaccine gets World Health Organization nod

Meanwhile, results, published in the Lancet previous year show Tybpar TCV to be 87 percent effective and can also be administered to children over six months old.

Typbar TCV, which got its license for clinical trials after 12 years of research in 2013, is of acceptable standards of quality, safety and efficacy, stated WHO.

Bharat Biotech's typhoid vaccine gets World Health Organization nod
Bharat Biotech's typhoid vaccine gets World Health Organization nod

This prequalification from World Health Organization is an important step to getting the vaccine made available in low-income countries. Typbar-TCV offers advantages over now available typhoid vaccines, including the ability to provide longer-lasting protection, require fewer doses, and be administered to children younger than two years of age, making it the first-ever to be approved for this age group. The WHO has recommended the use of typhoid conjugate vaccines on infants between 6 and 23 months of age and for children between 2 and 15 years of age. "SAGE also called for the introduction of TCV to be prioritized for countries with the highest burden of typhoid disease or of antibiotic resistance to Salmonella typhi".

Typhoid fever is caused by food and water contaminated by Salmonella Typhi (S Typhi) bacteria. The symptoms of the disease include fever, headache, nausea, loss of appetite, constipation and sometimes diarrhoea. "In some cases, patients have a rash of flat, rose-colored spots", according to the Centers for Disease Control and Prevention (CDC). In most developing countries, the cost of a course of typhoid fever treatment ranges from $50 to $5000 for outpatient and inpatient treatments, the company said. Travelers to Asia, Africa, and Latin America are especially at risk, and the highest risk for typhoid is in South Asia.

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"Typhoid is hugely underdiagnosed and most people are not given appropriate treatment, leading to antimicrobial resistance (AMR)".

About 22 million cases of typhoid fever and 200,000 related deaths occur worldwide each year.

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Bharat, which makes vaccines against nine other diseases, including one approved by the World Health Organization for polio, is developing immunisations against Ebola, chikungunya, Zika and non-typhoid strains of Salmonella.

People in close contact with a typhoid carrier. About 100 healthy volunteers in Oxford, England - many of them students - received the vaccine or a placebo, and then swallowed live Salmonella typhi. Now available typhoid vaccines fail to provide long term protection and protection for children below 2 years of age. Bharat Biotech is appreciative to Dr. John Robbins, who in 1999 trusted the team to deliver the promise of vaccines against typhoid fever.

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