Davis-Rea LTD Has Cut Celgene Corp (CELG) Holding by $3.79 Million
Mild TBI May Increase Risk of Parkinson's Disease
RCB beat DD by six wickets
Health Officials Warn 'Throw Romaine Lettuce Away'
Cholesterol drug significantly reduced patients' risk of death in trial
13 March 2018, 10:30 | Silvia Roy
Sanofi and Regeneron presented Odyssey outcomes data for Praluent at ACC 2018 on Saturday
The findings are welcome news for the drug's manufacturers, as the high list price has proven unpalatable to insurance companies.
Patients receiving Praluent also experienced a statistically valid reduction in the overall risk of death (hazard ratio = 0.85) versus control. "We are prepared to improve access and affordability, eliminating burdensome barriers for high-risk patients in need". That price would be tied to an independent review of Praluent's value based on the new risk reduction data from the multi-year study called Odyssey Outcomes. The MACE composite endpoint includes patients who experienced a heart attack, ischemic stroke, death from coronary heart disease (CHD), or unstable angina requiring hospitalization. The organization recommended a price range of $4,500 to $8,000 for those high-risk patients likely to gain the most benefit from Praluent therapy. The study, reported at the conference of the American College of Cardiology, involved 18,000 high-risk patients who had uncontrolled cholesterol despite taking a maximum amount of statins.
Praluent's impact on the actual number of deaths from coronary heart disease was modest, however, failing to reach statistical significance (p=0.38).
The findings described Saturday at the American College of Cardiology conference in Orlando, Florida, were based on an worldwide trial of almost 19,000 people randomly assigned to either alirocumab or a placebo.
"Many patients who have survived a recent heart attack or other coronary event are unable to reach an LDL cholesterol goal of less than 100 mg/dL, and have an urgent need for new therapeutic options due to their increased risk of another event".
"The results were not trivial", said Fuster, from Mount Sinai Hospital in NY. In the long-term trail patients on high-dose statin therapy had been randomised 1:1 for Pradulent combination and statin monotherapy and were treated for an average (median) of 2.8 years.
"It may take years and years to really reap all the benefits that one can achieve", study co-chairman Dr. Gregory Schwartz said.
Regeneron president and chief scientific officer George Yancopoulos said: "This trial was consistent with earlier statin trials, showing the greatest benefit in patients with higher cholesterol levels at baseline".
The trial was created to maintain patients' LDL-C levels between 25-50 mg/dL, using two different doses of alirocumab (75 mg and 150 mg).
Chiefs release veteran OLB Tamba Hali
Hali was the 20th overall pick in the 2006 draft out of Penn State, started every game as a rookie and never really looked back. He last made the Pro Bowl in 2015, when he recorded 8 tackles and 6 1/2 sacks in 15 games.
Jose Mourinho Scorches Frank De Boer Over Rashford Comments
Neither of those victorious sides were favourites for the crown and the Portuguese believes United are outsiders this time. Ex Inter and Crystal Palace manager Frank De Boer has slammed Jose Mourinho for his treatment towards Marcus Rashford .
Ryan Coogler pens tribute to one of his heroes Ava DuVernay
They are the affable, likeable sort who, much to Meg's chagrin, don't have the same kinds of problems fitting in that she does. Kaling does an exceptional job at alternating between her usual outspoken, comedic character and a more refreshing, wise Mrs.
Parties announce candidates: RS polls on Mar.23
BJP on Sunday released a list of candidates for the ensuing Biennial Election to Rajya Sabha for different states. Rajeev Chandrasekhar is among 18 candidates named by BJP for the Rajya Sabha polls.
Police approaches BCCI in Cricketer Shami case
Following the allegations, the Board of Control for Cricket in India (BCCI) withheld its annual contract with Shami. Lalabazar sources on Sunday said they have lodged a case based on the specific allegations made by Hasin.
Google Duo adds video messaging service
With video messages on Google Duo, users can now capture and share important moments, even when the receiver can't take the call. It looks like their newest guinea pig is to add the ability to send money on Google Contacts through the Google Pay Send app.
AJ Styles Must Retain At WWE Fastlane
The carnage ensues until Harper powerbombs Xavier Woods onto the steel steps, leading to medical personnel rushing to ringside. Daniel Bryan feels that Shane goes overboard in his hate for them and tries to balance it out by being supportive to them.