August 19, 2018

Blacks With Prostate Cancer May Fare Better Than Whites

05 June 2018, 07:29 | Silvia Roy

Image Some men with prostate cancer could live longer thanks to immunotherapy

Some men with prostate cancer could live longer thanks to immunotherapy

"Our study has found that immunotherapy can benefit a subset of men with advanced, otherwise untreatable prostate cancer, and these are most likely to include patients who have specific DNA fix mutations within their tumors", he said.

Researcher Prof Johann de Bono told the BBC: "This is the first evidence that a subset of prostate cancer patients do spectacularly well on immunotherapy".

Her report pooled results from nine studies in the U.S., Europe and Asia, and focused on the more than 7,000 whites and 500 blacks with advanced prostate cancer who had stopped responding to hormone therapy. "We need to look closely at the underlining genetic differences that associate with treatment response and build on that to improve survival for these patients".

George and colleagues enrolled 50 black men and 50 white men in a prospective, multi-center study.

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Nonetheless, for sufferers reminiscent of these within the new examine with docetaxel-refractory metastatic castration-resistant prostate most cancers, there may be at present no efficient therapy. "It is a new arrow in the quiver for men with lethal prostate cancer, it's a big deal for these patients". Prostate cancer can develop when cells in the prostate start to grow in an uncontrolled way.

"This study underscores the importance of increasing the participation of racial minorities in clinical trials".

The results will bring hope to men such as BBC presenter Bill Turnbull, 62, who in March revealed that he had been diagnosed with prostate cancer which had spread "to the bone".

The results of the trial, led by a team at the Institute of Cancer Research, London, and the Royal Marsden NHS Foundation Trust, will be presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago. About 164,690 men are diagnosed of the disease per year.

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"This is important as although immunotherapy is exciting, it can have severe side effects".

Dr. Adam Murphy, a Northwestern University physician who studies racial disparities in prostate cancer, said some reasons for low black enrollment in studies include poor overall health, money and mistrust of the medical establishment.

Professor Geoffrey Oxnard, of the Dana-Farber Cancer Institute in the U.S., said: 'The beauty of a blood test is it could just be done in a local GP office'.

Immunotherapy has become a treatment for cancer, particularly skin and lung cancers.

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