Pep Guardiola's Premier League leaders will go into the clash as favourites against a United side sitting seventh but beginning to rediscover their best form. Mourinho's team are enjoying a fine week, having won at Bournemouth and Juventus, while last month they drew at Chelsea after leading until the closing moments.
It was the 121st goal in the competition for five-time Champions League victor Ronaldo who Juventus are counting on to help them lift their first European title since 1996.
The win took United to seven points, two behind their hosts but crucially, two ahead of Valencia, with two matches left.
David Silva hopes Manchester City can give their fans the chance "to wind up the red half" with a win over United in the derby on Sunday. "The most important thing is the three points".
Instead they must now wait for the remaining games against Valencia and Young Boys to seal their passage to the next round.
"So I tried to do what I do in training a lot of times, practicing, practicing".
"We played a fantastic game, to our top level, as we can not be any better than this".
Juve were then left in shock as Ashley Young's free-kick from the left bounced in off a combination of Bonucci and Alex Sandro after a frantic scramble in front of goal. The love that they showed me today was unbelievable and how great is football when you see that?
"A point or three would've changed little for Juventus, but three points makes a big difference to us".
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He had some chances too. "When you are playing football , when you are playing in competitive matches, it can happen. The Arsenal forward's career has been plagued by injuries, and this could be the worst of the lot.
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And while Nelson may not be a ready-made replacement for Welbeck , Emery says he is keeping a keen eye on his progress. But I think the players were concentrated on the match and we forgot this injury the next minute on the pitch.
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Giroud told BT Sport: "It's true, I was hoping to score soon because I came back late from the World Cup and lacked a bit of luck. He added: "Today I was in trouble, too". "It's very important because then we can talk again about this competition in February".