techkenyot.com
techkenyot.com April 22, 2019


Insulin in a pill from MIT researchers

09 February 2019, 10:11 | Silvia Roy

Insulin in a pill from MIT researchers

Insulin in a pill from MIT researchers

Daily insulin injections given to people with diabetes may disappear in the future thanks to a capsule that releases insulin directly into the stomach, a technique that has been tested so far in pigs, according to a report published by the "Science" journal.

The pea-sized capsule contains a small needle made of solid, compressed insulin, which is injected into the stomach wall after the capsule has been swallowed.

In tests on animals, an MIT-led research group showed they could deliver enough insulin to lower blood sugar to levels comparable to those produced by doses administered through skin.

They also demonstrated that the device can be adapted to "deliver other protein drugs".

Hazard compares management style of Sarri to those of Mourinho and Conte
The Monaco midfielder thinks that because Hazard was reluctant to force his way out of the club, he will likely sign an extension. Given the outlook of his own career, he can perhaps be a little more laidback about Hazard's future.

Other authors of the study had, several years ago, developed a pill coated with many tiny needles that could be used to inject drugs into the stomach's lining or the small intestine. For the brand new capsule, the researchers modified the design to have only one needle, permitting them to keep away from injecting medicine into the inside of the abdomen, the place they'd be damaged down by abdomen acids earlier than having any impact.

Once the insulin was absorbed, the capsule, made of stainless steel and a biodegradable material, floated free and was excreted. The mechanism works by releasing a spring which is freed by dissolving a supporting sugar disk (water within the stomach causes the sugar disk to dissolve).

Because of the lack of pain sensors in the stomach wall, this injection is painless. To make sure that the drug is injected into the abdomen wall, the researchers designed their system so that irrespective of how the capsule lands within the abdomen, it may well orient itself, so the needle is involved with the liner of the stomach. And ever since, researchers have been attempting to find ways to deliver insulin orally without any success. When ingested this insulin gets injected into the stomach wall. "Our motivation is to make it easier for patients to take medication, particularly medications that require an injection", " Traverso said. "Although we need to investigate further, this could be a potential way to deliver many medications such as immune-suppressants to treat rheumatoid arthritis or inflammatory bowel diseases", said Traverso.

The researchers drew their inspiration for the self-orientation feature from a tortoise known as the leopard tortoise. U.S. scientist based the pill's design on the African leopard tortoise which has a shell with a high, steep dome, allowing it to right itself if it rolls onto its back.

Apple warns app developers to remove or disclose screen recording code
The first step, he says, is having companies be more honest about how they collect their users' data and who they share it with. Sadly, Glassbox is hardly the only one of its kind and that app analytics industry isn't going away any time soon.

"What's important is that we have the needle in contact with the tissue when it is injected", Abramson", said.

Once the contents from the capsule are released, it passes through the digestive system without any side effects.

One pill can reportedly deliver as much as 300 micrograms of insulin in one shot.

This work was funded in part by a Novo Nordisk grant, NIH Grant No. EB-000244, an NSF GRFP fellowship, the Division of Gastroenterology at Brigham and Woman's Hospital, the Viking Olaf Björk scholarship trust, and the MIT UROP program.

Marlins Demanding Prospect From Phillies In J.T. Realmuto Trade
The Nationals did not get Realmuto. "I think it's a good idea to date the person before you ask to marry them", Klentak said. Realmuto is considered an excellent handler of pitchers. "He will have a really big impact on our group".



Other News

Trending Now

Mazda celebrates 30 years of MX-5 with Anniversary Edition
Like all 2019 Miata's, the 30th Anniversary Edition relies on a 181-horsepower 2.0-liter four-cylinder engine for motivation. Yesterday Mazda pulled the wraps off a very special MX-5 Miata 30th Anniversary Edition at the Chicago Auto Show .

Sprint sues AT&T over ‘5G E’ icon as marketing claims heat up
I have personally already encountered AT&T customers who believe their Samsung phone now has 5G. T-Mobile also hit out at the firm, accusing it of "duping customers" with the move.

Suns acquire Heat's Johnson
The Phoenix Suns and Miami Heat joined forced for a little bit of salary-dumping trade action on Wednesday afternoon. He is best known for his hustle that often left him with missing teeth and other aggression-related injuries.

UAE Arming Militias in Yemen With Weapons From Western Countries - New Investigation
In December, a similar bill cleared the Senate in a 56-41 vote but was blocked by the House, which was then under the control of Republicans.

Venezuela's humanitarian aid standoff
It's possible the Venezuelan government fears aid crossing the border could be used as cover for an invasion to depose Maduro . The bridge is at the same site where officials plan to store humanitarian aid that Guaido is vowing to deliver to Venezuela.

Ireland's Kearney set for 6 Nations return
Toner is the third Ireland lock lost to injury after Iain Henderson and Tadhg Beirne. He's coming back to form after a long lay-off'.

Measles breaks out across the Philippines after Dengvaxia vaccine scare
On Thursday, Dr Duque declared that there was also an outbreak in central and southern Luzon and in central and western Visayas. The DOH Epidemiology Bureau (DOH EB) has reported almost 200 confirmed cases through January 19 in the region.

At least two killed in building collapses in Turkey's Istanbul
Turkish emergency services said Havva Tekgoz was found 18 hours after the collapse, and she was immediately rushed to hospital. Rescuers carry an injured woman on a stretcher from the site of a collapsed building in Turkey , Feb. 7, 2019.

Baby left on Ohio train as father steps out to smoke
According to a police statement, the father was accused of acting "menacing" towards the train operator after the fact. The incident took place on a Rapid Transit train as it departed Windermere Station in Cleveland, Ohio , last month.

Maduro: Venezuelans not ‘beggars,’ give humanitarian aid to Colombians
The 35-year-old argues Maduro was re-elected last year in a sham vote and the country must hold new presidential elections. Ambassador to Colombia Kevin Whitaker said the U.S. will get supplies to the border, and Guaido will take it from there.