techkenyot.com
techkenyot.com May 22, 2019


A cure for HIV? Feasible but not yet realized

10 March 2019, 06:21 | Silvia Roy

A cure for HIV? Feasible but not yet realized

A cure for HIV? Feasible but not yet realized

While bone marrow transplants aren't likely to become standard HIV treatment, Deeks said there's promising research in using gene therapy to alter the CCR5 receptors.

The Dusseldorf patient also received a bone marrow transplant from a donor with the CCR5 mutation.

But just like the protease inhibitors and triple therapy were not a cure in 1996, the eradication of HIV from the bodies of two men across more than a dozen years undergoing stem cell or bone marrow transplants with cells that have the CCR5 genetic mutation is simply not the promise of an impending cure for HIV for at least four important reasons: it is highly unsafe; it is extremely expensive; it is not scalable; and it is not sustainable.

Monthly shots of HIV drugs worked as well as daily pills to control the virus that causes AIDS in two large worldwide tests, researchers reported Thursday.

Gold steadies as European Central Bank stance drag equities; U.S
There was also a chance the jobless rate could fall by more than forecast given the recent strength in employment. MSCI's broadest index of Asia-Pacific shares outside Japan skidded 1.1 percent to a two-week trough.

This announcement at the Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle comes just two days after the second person in history was announced to be HIV-free on Monday, March 4.

The first such case of an HIV patient being cleared of the virus after a bone marrow transplant happened a decade ago to Timothy Brown, known as the "Berlin patient", who is still free of the virus.

Over 400 representatives from government agencies, global organisations, community-based organisations working with HIV patients, people living with HIV, and media agencies attended the four events. It is typically reserved only for patients who have late-stage cancer and for whom standard cancer treatments have otherwise failed. It is not sustainable, because the CCR5 genetic mutation is also extremely rare, and it is present only in less than 5 percent of individuals born of European dissent.

Earlier this week, researchers announced that they were able to cure the another person's HIV.

Facebook steps up effort to rid site of vaccine misinformation
Recently, another social media platform , Pinterest , suspended all searches for anything related to vaccines. By reducing their rank, such groups and pages don't show up on the News Feed and Searches of other people.

Before Tuesday some researchers had posited a third theory: that it was the intense combination of radiation and chemotherapy ahead of the stem-cell transplant that floored the virus. The Berlin patient had his immune cells replaced with ones from a donor with a genetic mutation that disables a receptor called CCR5.

Walker said another positive sign with this second cure is that in the first case, the transplant nearly killed the patient, but in this case, it did not. It also suggests that this is a promising avenue to pursue in our quest for a long-term HIV cure. Scientists have been monitoring his blood closely, and only one test in that time showed any traces of the virus; they suggest that result could be due to contamination of the test. Maybe the treatment worked exactly as doctors had hoped and allowed his body to build a new immune system that was both cancer-free and protective against HIV.

There are now around 37 million people living with HIV worldwide, and the virus claims around 1 million lives annually. Cells without a working CCR5 receptor are essentially locked up to the virus. For starters, there are two main variants of HIV, one of which is much rarer than the other - and all three patients had the rare variant. Instead of having to keep in mind to take pills, patients instead could get injections from a doctor or nurse each month.

While it proved to be successful for the Berlin, London, and Düsseldorf patients, the strategy used for these cases are not the way to eradicate HIV on a large scale.

Brown won't enter crowded race for White House
Not only are other candidates starting to talk about the dignity of work, voters across the country are demanding it. He said has never aspired to be president and, in the end, decided he could do the most good in the Senate.



Other News

Trending Now

A bitter cold start to our Monday
Our in house model predicts wind chill values of -25° to -30° area wide by 6am. Side streets will still be snow-packed and icy for the Monday morning drive.

Jason Day Withdraws From Bay Hill With Back Injury
I couldn't play at 100 percent today, so I just wanted to see if I could get out there and it may have loosened up. Day said he hoped to be ready to play next week's Players Championship, which he won in 2016.

Meghan avoids Twitter so she doesn't get muddled by the 'noise'
When asked by the event's chairwoman and senior editor of The Economist Anne McElvoy if she looked at Twitter , she said , "No, sorry no".

Kevin Zeitler an instant upgrade to Giants' weak offensive line
He played linebacker in the Giants' 3-4 defensive scheme last season, but has played at defensive end in a 4-3 package. Three years after being the crown jewel of the Giants' free agent spending spree, Olivier Vernon is on the move.

Jennifer Lopez and Alex Rodriguez get engaged
Rodriguez wrote in the post, "She said yes", alongside a photo of Lopez's hand with a massive diamond ring. The duo announced on Instagram that they're engaged after just over two years of dating.

When will Bryce Harper play for the Phillies in spring training?
Harper said Wednesday he hasn't spoken with MLB about his comments, which could be a violation of the league's tampering rules. Bobby Abreu coaching Phillies outfielder Bryce Harper . yeah, it's not something you ever thought would happen.

International Women's Day Facts You Need to Know
In 1975, the United Nations began celebrating International Women's Day , which had by then moved to March 8. Organizers reportedly plan to protest against poverty and unpaid labor that often falls upon women.

Venezuela left in the dark as United States sabotage blamed for blackout
On Thursday, the Venezuelan capital of Caracas and 20 of the country's 23 regions were left without electricity. Guaido says Maduro's rule is illegitimate, arguing that his re-election win past year was fraudulent.

Solskjaer says Molde contract ended, plays down his Manchester United prospects
Paul Pogba is back from suspension, while Anthony Martial , Nemanja Matic and Ander Herrera could be fit to return from injury.

Finnish government resigns after healthcare reform fails
President Sauli Niinistö accepted the resignation and asked Mr Sipila's government to continue in office until the elections. The changes were crucial to the three-party governing coalition's plan to balance public finances.