World number 113 Krajinovic was aiming to become the first qualifier in 16 years to make the last eight at this tournament, but he was simply outclassed by the 17-time major victor. Isner fought back in the second set after Karen took the helm in first one but neither player was able to take their chances.
Defending champ Osaka blitzed by Bencic
Hurkacz, unseeded, reached the fourth round of a Masters 1000 event for the first time in his career. She began this year winning the Australian Open and moving to the top of the rankings.
NASA boss says first Martian 'likely to be a woman'
The agency is now exploring options for meeting that deadline using "commercial capabilities", Bridenstine said . It also decided that private companies would launch a probe towards Jupiter's moon Europa.
Tyreek Hill investigated for battery, report says
Hill completed his probation in August, causing the domestic-abuse charges to be dismissed and his record to be expunged. They also reported that Hill's name was not mentioned in their report, but his fiancee, Crystal Espinal, is mentioned.